Proteomics in functional genomics (Birkhauser Verlag AG)

A wealth of information has accumulated over the last few years on the §human genome. The new insights have completely changed the focus of §protein analysis. It is no longer time-consuming analysis of unknown §products, but rather selective identifications of individual forms, §modifications and processings, and overall analysis of global protein §outputs from cells and tissues in health and disease. §This book gears to the rising need of sensitive, accurate, and fast §separation and identification techniques in proteomics. It discusses §current methodologies of modern protein analysis, from isolation and §sample preparation, over analysis and identification, to final §characterization. Several evaluations concentrate on the now productive §approaches of two-dimensional gel electrophoresis and mass spectrometry, §but alternative methods and further perspectives are also outlined. The §book includes an overlook over current databases to connect protein §analysis data with all available information,...