In recent years, Botulinum toxins have made their way into Prosthodontics for both Dental Aesthetic and therapeutic uses. They are here to stay and with more intra oral uses of these materials, they are fast becoming an integral part of everyday dental practice. They provide most significant, minimally invasive procedure at low cost with limited to no recovery time.Today Botox go for rejuvenative and cosmetic procedures. Botox has important clinical uses as an adjunct therapy in Prosthodontics and for patients with bronic TMJ and facial pain. Botox is also used to complement aesthetics as a minimally invasive alternative to surgically treating high lip- line cases for complete denture patients who have trouble adjusting to new dentures, gummy smiles, lip augmentation and also retraining of the facial muscles.BOTOX has no doubt broadened the horizon of dentistry and is alluring the dentists all over the world to bring it into their clinical practices.